Recombinant Human IRF4

• Cat.No.: IRF4-28543TH
• Product Overview: Recombinant fragment, corresponding to amino acids 144-451 of Human MUM1, Q15306

Specification

• Description: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Tissue specificity: Lymphoid cells.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Gene Information

• Gene Name: IRF4 interferon regulatory factor 4 [ Homo sapiens ]
• Official Symbol: IRF4
• Synonyms: IRF4; interferon regulatory factor 4; MUM1; LSIRF
• Gene ID: 3662
• mRNA Refseq: NM_001195286
• Protein Refseq: NP_001182215
• MIM: 601900
• Uniprot ID: Q15306
• Chromosome Location: 6p25-p23
• Pathway: Apoptosis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor binding