Recombinant Human JUN
Cat.No. : | JUN-27752TH |
Product Overview : | Recombinant fragment: MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERL, corresponding to N terminal amino acids 1-79 of Human c-Jun with N-terminal proprietary tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MTAKMETTFYDDALNASFLPSESGP YGYSNPKILKQSMTLNLADPVGSLK PHLRAKNSDLLTSPDVGLLKLASPE LERL |
Sequence Similarities : | Belongs to the bZIP family. Jun subfamily.Contains 1 bZIP domain. |
Gene Name : | JUN jun proto-oncogene [ Homo sapiens ] |
Official Symbol : | JUN |
Synonyms : | JUN; jun proto-oncogene; jun oncogene , v jun avian sarcoma virus 17 oncogene homolog , v jun sarcoma virus 17 oncogene homolog (avian); transcription factor AP-1; AP 1; c Jun; |
Gene ID : | 3725 |
mRNA Refseq : | NM_002228 |
Protein Refseq : | NP_002219 |
MIM : | 165160 |
Uniprot ID : | P05412 |
Chromosome Location : | 1p32-p31 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of the AP-1 family of transcription factors, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; |
Function : | DNA binding; R-SMAD binding; Rho GTPase activator activity; double-stranded DNA binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
JUN-2802R | Recombinant Rat JUN Protein, His (Fc)-Avi-tagged | +Inquiry |
JUN-4693M | Recombinant Mouse JUN Protein, His (Fc)-Avi-tagged | +Inquiry |
JUN-2156R | Recombinant Rhesus Macaque JUN Protein, His (Fc)-Avi-tagged | +Inquiry |
JUN-292H | Recombinant Human JUN protein, His/MBP-tagged | +Inquiry |
JUN-3146R | Recombinant Rat JUN Protein | +Inquiry |
◆ Lysates | ||
JUN-5095HCL | Recombinant Human JUN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere are currently no drugs that directly regulate the expression level of JUN, but some JUN-related diseases can be treated by inhibiting its activity or regulating its expression.
JUN has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
Mutations in JUN can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
The types of mutations in JUN include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Studying the regulatory mechanism of JUN requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
JUN plays an important role in the cell cycle, which can promote the transition of cells from G1 phase to S phase and promote cell proliferation and differentiation.
Customer Reviews (3)
Write a reviewThe stability of the protein indicates ease of storage.
High biological activity.
Highly expressed in the expression system.
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