Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human KCNJ11

Cat.No. : KCNJ11-29900TH
Product Overview : Recombinant fragment corresponding to amino acids 301-390 of Human Kir6.2 with an N terminal proprietary tag; Predicted MWt 35.53 kDa inclusive of tag.
  • Specification
  • Gene Information
  • Related Products
Description : Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Protein length : 90 amino acids
Molecular Weight : 35.530kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : RTSYLADEILWGQRFVPIVAEEDGR YSVDYSKFGNTVKVPTPLCTARQLD EDHSLLEALTLASARGPLRKRSVPM AKAKPKFSISPDSLS
Gene Name : KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11 [ Homo sapiens ]
Official Symbol : KCNJ11
Synonyms : KCNJ11; potassium inwardly-rectifying channel, subfamily J, member 11; ATP-sensitive inward rectifier potassium channel 11; BIR; Kir6.2;
Gene ID : 3767
mRNA Refseq : NM_000525
Protein Refseq : NP_000516
MIM : 600937
Uniprot ID : Q14654
Chromosome Location : 11p15.1
Pathway : ATP sensitive Potassium channels, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Inwardly rectifying K+ channels, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function : ATP binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; potassium ion binding; protein C-terminus binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All KCNJ11 Products

Required fields are marked with *

My Review for All KCNJ11 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends