Recombinant Human KDM1A

• Cat.No.: KDM1A-29892TH
• Product Overview: Recombinant fragment corresponding to amino acids 158-852 of Human KDM1 / LSD1 with N-terminal proprietary tag, 103 kDa.

Specification

• Description: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Tissue specificity: Ubiquitously expressed.
• Biological activity: Specific Activity: 0.82 pmole/min/μg.Assay buffer: 50 mM sodium phosphate, pH 7.4, 70 uM dimethylated H3-K4 peptide and 8 ng/ul recombinant KDM1 / LSD1, 30 min at 37°C.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the flavin monoamine oxidase family.Contains 1 SWIRM domain.

Gene Information

• Gene Name: KDM1A lysine (K)-specific demethylase 1A [ Homo sapiens ]
• Official Symbol: KDM1A
• Synonyms: KDM1A; lysine (K)-specific demethylase 1A; amine oxidase (flavin containing) domain 2 , AOF2, KDM1, lysine (K) specific demethylase 1; lysine-specific histone demethylase 1A; BHC110; KIAA0601; LSD1
• Gene ID: 23028
• mRNA Refseq: NM_001009999
• Protein Refseq: NP_001009999
• MIM: 609132
• Uniprot ID: O60341
• Chromosome Location: 1p36.12
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem
• Function: MyoD binding; androgen receptor binding; chromatin binding; demethylase activity; enzyme binding