Recombinant Human KDR, His-tagged
Cat.No. : | KDR-31715TH |
Product Overview : | Recombinant fragment from Human VEGFR2; M.Wt 116 kDa. Glycosylated monomer.This protein consists of all 7 extracellular domains, which contain all the information necessary for high affinity ligand binding.Source: Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. |
Conjugation : | HIS |
Form : | Lyophilised:Reconstitute in water or PBS to a concentration of not lower than 100 μg/ml. |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 100mM Sodium chloride, 10mM Tris, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain. |
Gene Name : | KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ] |
Official Symbol : | KDR |
Synonyms : | KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; |
Gene ID : | 3791 |
mRNA Refseq : | NM_002253 |
Protein Refseq : | NP_002244 |
MIM : | 191306 |
Uniprot ID : | P35968 |
Chromosome Location : | 4q11-q12 |
Pathway : | Angiogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; |
Function : | ATP binding; Hsp90 protein binding; growth factor binding; integrin binding; nucleotide binding; |
Products Types
◆ Lysates | ||
KDR-417HCL | Recombinant Human KDR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1609 | KDR Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket