Native Human KLK1

• Cat.No.: KLK1-29685TH
• Product Overview: Full length native Human Kallikrein 1 from Human plasma, 86-88kDa.

Specification

• Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
• Tissue specificity: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
• Biological activity: Activity: 15 units per mg. One unit is defined as the amount of enzyme that hydrolyzes one umole of D-Pro-Phe-Arg-pNA per minute at 25°C, pH 7.8.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM Tris HCl, 100mM Sodium chloride, pH 7.8
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -20oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.

Gene Information

• Gene Name: KLK1 kallikrein 1 [ Homo sapiens ]
• Official Symbol: KLK1
• Synonyms: KLK1; kallikrein 1; kallikrein 1, renal/pancreas/salivary; kallikrein-1; Klk6
• Gene ID: 3816
• mRNA Refseq: NM_002257
• Protein Refseq: NP_002248
• Uniprot ID: P06870
• Chromosome Location: 19q13.3
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem
• Function: peptidase activity; serine-type endopeptidase activity