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Cat.
No. |
IL12RB1-1649H |
|
Description |
Interleukin 12 receptor, beta 1 (IL12RB1) also known as CD212 (cluster
of differentiation 212) is a subunit of the interleukin 12 receptor.
IL12RB1 is a type I transmembrane protein that belongs to the
hemopoietin receptor superfamily. This protein binds to interleukine 12
(IL12) with a low affinity, and is thought to be a part of IL12 receptor
complex. This protein forms a disulfide-linked oligomer, which is
required for its IL12 binding activity. IL-12 Rβ1 defect is generally
associated with selective susceptibility to weakly pathogenic
mycobacteria and Salmonella species. |
|
Source |
NSO
Cells. |
|
State Of Matter |
Lyophilized. |
|
Purity |
>95% by
SDS Page and analyzed by silver stain. |
|
Endotoxin |
<1.0 EU/µg
as determined by the LAL method. |
|
Molecular Weight |
The
predicted molecular weight of Recombinant Human IL-12 Rβ1 is Mr 84.5 kDa.
However, the actual molecular weight as observed by migration on SDS
Page is Mr 110 kDa. |
|
Storage And Stability |
This
lyophilized protein is stable for six to twelve months when stored
desiccated at -20oC to -70oC. After aseptic reconstitution, this protein
may be stored at 2oC to 8oC for one month or at -20oC to -70oC in a
manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
|
Gene
Information
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Gene
Name |
IL12RB1 interleukin 12 receptor, beta 1 [ Homo sapiens ] |
|
Synonyms |
interleukin 12 receptor, beta 1; CD212; IL12RB; MGC34454; IL-12R-BETA1;
IL12RB1; IL-12 receptor beta component; interleukin-12 receptor beta-1
chain; IL-12R-beta-1; IL-12RB1; IL12R; CD212 antigen; Interleukin-12
receptor beta |
|
GeneID |
3594 |
|
mRNA
Refseq |
NM_005535 |
|
Protein
Refseq |
NP_005526 |
|
MIM |
601604 |
|
UniProt
ID |
P42701 |
|
Chromosome Location |
19p13.1 |
|
Pathway |
Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
|
Function |
cytokine receptor activity |
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