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Recombinant Human LAMP2

Cat.No. : LAMP2-27946TH
Product Overview : Recombinant fragment corresponding to amino acids 30-127 of Human LAMP2 with a N terminal propriatery tag; predicted MWt 6.41 kDa inclusive of tag.
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  • Gene Information
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Description : The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins.
Protein length : 98 amino acids
Molecular Weight : 36.410kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : ELNLTDSENATCLYAKWQMNFTVRY ETTNKTYKTVTISDHGTVTYNGSIC GDDQNGPKIAVQFGPGFSWIANFTK AASTYSIDSVSFSYNTGDNTTFP
Sequence Similarities : Belongs to the LAMP family.
Gene Name : LAMP2 lysosomal-associated membrane protein 2 [ Homo sapiens ]
Official Symbol : LAMP2
Synonyms : LAMP2; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; CD107b;
Gene ID : 3920
mRNA Refseq : NM_001122606
Protein Refseq : NP_001116078
MIM : 309060
Uniprot ID : P13473
Chromosome Location : Xq24-q25
Pathway : Hemostasis, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does LAMP2 protein function in the context of cardiovascular diseases? 06/10/2022

LAMP2 may play a role in maintaining cardiac function and the clearance of damaged organelles in the heart, making it relevant to cardiovascular diseases.

How are mutations in the LAMP2 gene detected in clinical practice? 05/01/2022

Mutations in the LAMP2 gene can be identified through genetic testing, such as DNA sequencing.

What are the potential therapeutic implications of targeting LAMP2 in Danon disease? 04/25/2022

Targeting LAMP2 function or expression may represent a potential therapeutic strategy for treating Danon disease and other lysosomal storage disorders.

What are the clinical implications of LAMP2 deficiency? 02/08/2018

LAMP2 deficiency has been associated with Danon disease, a rare genetic disorder characterized by cardiomyopathy, skeletal myopathy, and intellectual disability.

How is LAMP2 protein involved in lysosomal function? 05/25/2017

LAMP2 is involved in maintaining the integrity and stability of lysosomal membranes, as well as facilitating the fusion of lysosomes with autophagosomes during autophagy.

Customer Reviews (3)

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Reviews
12/20/2021

    LAMP2 is extensively used in protein electron microscopy structure analysis due to its compatibility with this technique, providing crucial insights into molecular architectures.

    12/11/2017

      One aspect that sets the LAMP2 Protein apart is the excellent technical support provided by the manufacturer.

      08/07/2016

        I have found the LAMP2 Protein to be highly stable, enabling long-term experiments without compromising its performance.

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