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Recombinant Human LTA, His-tagged

Cat.No. : LTA-31536TH
Product Overview : Recombinant full length mature Human TNF beta with His tag, produced in the endosperm tissue of barley grain ; 187 amino acids with tag, Predicted MWt 20.8 kDa.
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  • Gene Information
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Description : The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.
Conjugation : HIS
Biological activity : Bioactivity:The ED50 is determined by the Cytotoxicity Assay for Human TNF beta for dose-dependent cytolytic effects of serial dilutions of hTNF beta on the fibrosarcoma L-929 cells.The ED50 lies in the range of 1.0-1.6 ng/ml corresponding to 1.0-0.6 x106
Form : Lyophilised:Reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS, pH 7.2
Storage : The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
Sequence Similarities : Belongs to the tumor necrosis factor family.
Gene Name : LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
Official Symbol : LTA
Synonyms : LTA; lymphotoxin alpha (TNF superfamily, member 1); TNFB; lymphotoxin-alpha; LT; TNFSF1;
Gene ID : 4049
mRNA Refseq : NM_000595
Protein Refseq : NP_000586
MIM : 153440
Uniprot ID : P01374
Chromosome Location : 6p21.3
Pathway : Apoptosis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function : cytokine activity; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some potential therapeutic applications of LTA protein? 02/21/2023

LTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.

Are there any clinical trials involving LTA protein? 06/22/2022

Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.

What are some potential side effects or adverse reactions associated with LTA protein therapy? 03/19/2021

Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.

Can LTA protein be used to treat autoimmune diseases? 08/11/2018

LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.

Can LTA protein be used in cancer treatment? 04/05/2017

LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.

Customer Reviews (3)

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Reviews
04/14/2020

    Its purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.

    01/03/2020

      Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.

      08/24/2017

        The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.

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