Recombinant Human MAPK12

• Cat.No.: MAPK12-31377TH
• Product Overview: Recombinant full-length human SAPK3 with a N-terminal tag.

Specification

• Description: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
• Tissue specificity: Highly expressed in skeletal muscle and heart.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAPK12 mitogen-activated protein kinase 12 [ Homo sapiens ]
• Official Symbol: MAPK12
• Synonyms: MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3
• Gene ID: 6300
• mRNA Refseq: NM_002969
• Protein Refseq: NP_002960
• MIM: 602399
• Uniprot ID: P53778
• Chromosome Location: 22q13.3
• Pathway: Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CDO in myogenesis, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem
• Function: ATP binding; MAP kinase activity; magnesium ion binding; nucleotide binding; protein binding