Recombinant Human Interleukin 5 Receptor, Alpha
Cat.No. : | IL5RA-1646H |
- Specification
- Gene Information
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Cat. No. : | IL5RA-1646H |
Description : | The functional IL-5 receptor is a heteromeric complex consisting of an alpha and beta subunit. The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors. Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the α-chain. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor. In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction.Soluble IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP). |
Source : | Sf 21 Insect Cells. |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-5 sRα is Mr 38 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 43 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | IL5RA interleukin 5 receptor, alpha [ Homo sapiens ] |
Synonyms : | IL5RA; interleukin 5 receptor, alpha; CD125; CDw125; HSIL5R3; IL5R; MGC26560; CD125 antigen; OTTHUMP00000115373; OTTHUMP00000206893; OTTHUMP00000206896; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; interleukin-5 receptor alpha subunit; OTTHUMP00000115257; IL-5R-alpha |
Gene ID : | 3568 |
mRNA Refseq : | NM_000564 |
Protein Refseq : | NP_000555 |
MIM : | 147851 |
UniProt ID : | Q01344 |
Chromosome Location : | 3p26-p24 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage |
Function : | interleukin-5 receptor activity; protein binding |
Products Types
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IL5RA-5176H | Recombinant Human IL5RA Protein | +Inquiry |
◆ Lysates | ||
IL5RA-2060HCL | Recombinant Human IL5RA cell lysate | +Inquiry |
IL5RA-001MCL | Recombinant Mouse IL5RA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionRecombinant IL5RA can be used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. It can reduce the frequency and severity of asthma attacks by blocking the signaling of interleukin 5.
Currently, recombinant IL5RA is mainly used to treat IL5-related diseases, such as severe asthma and eosinophilic diseases. For other diseases, the suitability of IL5RA is subject to further research and clinical trials.
During the use of IL5RA, the doctor may ask to check the patient's blood routine regularly to monitor changes in blood counts and related indicators. This helps to evaluate the efficacy of the treatment and the safety of the patient.
There is no clear evidence that long-term use of recombinant IL5RA causes dependence. For patients using IL5RA, it is best to treat and discontinue the drug according to the advice and guidance of their doctor.
IL5RA is generally administered by subcutaneous injection. The specific use method and dosage should be determined according to the doctor's recommendation and the specific situation of the patient.
Common side effects of recombinant IL5RA include pain at the injection site, redness and swelling at the injection site, cough, and sore throat. A small number of patients may experience allergic reactions or serious adverse reactions, so close monitoring of the patient's condition and signs is required when using.
Customer Reviews (3)
Write a reviewGood stability under different temperature and humidity conditions.
In the process of purification, the removal of impurities is good.
Chemical modifications, such as PEGylation or glycosylation, have little effect.
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