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Recombinant Human MBD3, His-tagged

Cat.No. : MBD3-28525TH
Product Overview : Recombinant fragment, corresponding to amino acids 164-291 of Human MBD3 with N terminal His tag; Predicted MWt 15 kDa.
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Description : DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3.MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:Reconstitute with 86 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : GLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKN PGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEE ALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEE EEPDPDPEMEHV
Sequence Similarities : Contains 1 MBD (methyl-CpG-binding) domain.
Gene Name : MBD3 methyl-CpG binding domain protein 3 [ Homo sapiens ]
Official Symbol : MBD3
Synonyms : MBD3; methyl-CpG binding domain protein 3; methyl-CpG-binding domain protein 3;
Gene ID : 53615
mRNA Refseq : NM_003926
Protein Refseq : NP_003917
MIM : 603573
Uniprot ID : O95983
Chromosome Location : 19p13
Pathway : Signaling events mediated by HDAC Class I, organism-specific biosystem;
Function : DNA binding; chromatin binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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