Recombinant Human Interleukin 9
Cat.No. : | IL9-216H |
Product Overview : | Recombinant Human interleukin 9 sequence encoding the 126 amino acid human IL-9 protein sequence was inserted into a suitable expression vector and was expressed inSf 21 insect cellsusing a baculovirus expression system. |
- Specification
- Gene Information
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Cat. No. : | IL9-216H |
Description : | Interleukin 9, also known as IL9, is a TH2 cytokine belonging to the group of interleukins. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. IL-9 stimulates the proliferation of a variety of hematopoietic lineages through its interaction with a receptor of the cytokine receptor superfamily. IL-9 plays a role in the complex pathogenesis of bronchial hyperresponsiveness as a risk factor for asthma. |
Source : | Sf 21 Insect Cells. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-9 is Mr 16-25 kDa. The protein resolves into multiple bands within this range on SDS-Page. |
State Of Matter : | Lyophilized. |
Formulation : | This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. |
Purity : | > 97% by SDS Page and analyzed by silver stain. |
Endotoxin : | < 0.1 ng per 1 µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human IL-9 was determined by its ability to stimulate cell proliferation in the factor-dependent human megakaryocytic leukemic cell line, M07e. The expected ED50 for this effect is typically 0.5 - 1.0 ng/mL. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | IL9 interleukin 9 [ Homo sapiens ] |
Synonyms : | IL9; interleukin 9; P40; HP40; IL-9; p40 T-cell and mast cell growth factor; T-cell growth factor p40; p40 cytokine; homolog of mouse T cell and mast cell growth factor 40; OTTHUMP00000159423 |
Gene ID : | 3578 |
mRNA Refseq : | NM_000590 |
Protein Refseq : | NP_000581 |
UniProt ID : | P15248 |
Chromosome Location : | 4q13-q21 |
MIM : | 146931 |
Pathway : | Asthma; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
Function : | cytokine activity; cytokine receptor binding; growth factor activity |
Products Types
◆ Recombinant Protein | ||
Il9-1060R | Recombinant Rat Il9 Protein, His-tagged | +Inquiry |
IL9-218H | Recombinant Active Human IL9 Protein, His-tagged(N-ter) | +Inquiry |
IL9-5165H | Recombinant Human IL9 Protein, GST-tagged | +Inquiry |
IL9-192H | Active Recombinant Human IL9 Protein | +Inquiry |
IL9-4521M | Recombinant Mouse IL9 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL9-618HCL | Recombinant Human IL9 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSeveral clinical trials are currently underway to evaluate the safety and effectiveness of IL9 in treating conditions such as asthma and allergies. However, the research is still in its early stages and more data are needed.
IL9 can be synthesized in the laboratory by biotechnological methods. Before clinical use, it needs to go through strict quality control and testing.
By binding to specific receptors, IL9 can activate relevant signaling pathways and regulate the development and function of immune cells. It can affect the activity of a variety of immune cells, such as T cells and macrophages.
IL9 has cross-action with other cytokines, which can regulate the expression and function of each other. For example, IL9 can promote the production of IL4 and IL13, and IL4 and IL13 can also promote the secretion of IL9.
IL9 can be used to treat certain inflammatory diseases, such as asthma and skin allergies. It can regulate the response of the immune system and reduce the symptoms of related diseases.
The mechanism of action of IL9 in asthma treatment is not fully understood, but studies have shown that it can reduce the infiltration of inflammatory cells and the release of inflammatory mediators, thereby reducing the symptoms of asthma.
Customer Reviews (3)
Write a reviewThe anti-interference ability of IL9 was excellent in Western blot, which avoided the interference problem in the experiment.
This protein has high catalytic efficiency, high safety and high expression level, and is a precious resource in the field of scientific research.
The reproducibility of IL9 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.
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