Recombinant Human MTOR
Cat.No. : | MTOR-30254TH |
Product Overview : | Recombinant fragment of Human mTOR with proprietary tag at the N terminal; Predicted MW 36.63 kDa, inclusive of tag. |
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- Specification
- Gene Information
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Description : | The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Expressed in numerous tissues, with highest levels in testis. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | WGLGQWDSMEEYTCMIPRDTHDGAF YRAVLALHQDLFSLAQQCIDKARDL LDAELTAMAGESYSRAYGAMVSCHM LSELEEVIQYKLVPERREIIRQIWW |
Sequence Similarities : | Belongs to the PI3/PI4-kinase family.Contains 1 FAT domain.Contains 1 FATC domain.Contains 7 HEAT repeats.Contains 1 PI3K/PI4K domain. |
Gene Name : | MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens ] |
Official Symbol : | MTOR |
Synonyms : | MTOR; mechanistic target of rapamycin (serine/threonine kinase); FK506 binding protein 12 rapamycin associated protein 1 , FRAP, FRAP1, FRAP2; serine/threonine-protein kinase mTOR; dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1); FK506 |
Gene ID : | 2475 |
mRNA Refseq : | NM_004958 |
Protein Refseq : | NP_004949 |
MIM : | 601231 |
Uniprot ID : | P42345 |
Chromosome Location : | 1p36 |
Pathway : | AMPK signaling, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; |
Function : | ATP binding; RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; TFIIIC-class transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
MTOR-5792M | Recombinant Mouse MTOR Protein, His (Fc)-Avi-tagged | +Inquiry |
Mtor-4222M | Recombinant Mouse Mtor Protein, Myc/DDK-tagged | +Inquiry |
MTOR-22H | Recombinant Human MTOR Protein, GST tagged | +Inquiry |
MTOR-3474R | Recombinant Rat MTOR Protein, His (Fc)-Avi-tagged | +Inquiry |
Mtor-1798M | Recombinant Mouse Mtor Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MTOR-4068HCL | Recombinant Human MTOR 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.
Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.
The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.
Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.
Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.
Customer Reviews (3)
Write a reviewWith its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.
The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.
One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.
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