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Recombinant Human MTOR

Cat.No. : MTOR-30254TH
Product Overview : Recombinant fragment of Human mTOR with proprietary tag at the N terminal; Predicted MW 36.63 kDa, inclusive of tag.
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Description : The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in numerous tissues, with highest levels in testis.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : WGLGQWDSMEEYTCMIPRDTHDGAF YRAVLALHQDLFSLAQQCIDKARDL LDAELTAMAGESYSRAYGAMVSCHM LSELEEVIQYKLVPERREIIRQIWW
Sequence Similarities : Belongs to the PI3/PI4-kinase family.Contains 1 FAT domain.Contains 1 FATC domain.Contains 7 HEAT repeats.Contains 1 PI3K/PI4K domain.
Gene Name : MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens ]
Official Symbol : MTOR
Synonyms : MTOR; mechanistic target of rapamycin (serine/threonine kinase); FK506 binding protein 12 rapamycin associated protein 1 , FRAP, FRAP1, FRAP2; serine/threonine-protein kinase mTOR; dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1); FK506
Gene ID : 2475
mRNA Refseq : NM_004958
Protein Refseq : NP_004949
MIM : 601231
Uniprot ID : P42345
Chromosome Location : 1p36
Pathway : AMPK signaling, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem;
Function : ATP binding; RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; TFIIIC-class transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does dysregulation of the MTOR pathway contribute to the development of certain diseases? 01/01/2022

Dysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.

How does the MTOR pathway influence the response to immunotherapy in cancer treatment? 04/19/2021

Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.

What are the mechanisms through which the MTOR pathway contributes to drug resistance in cancer? 01/24/2020

The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.

How can the knowledge of the MTOR pathway be leveraged to develop novel cancer therapies? 02/28/2019

Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.

What are the implications of MTOR pathway dysregulation in metabolic disorders? 08/28/2018

Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.

Customer Reviews (3)

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12/27/2020

    With its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.

    02/16/2019

      The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

      12/01/2016

        One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.

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