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Recombinant Human MYO1A

Cat.No. : MYO1A-30273TH
Product Overview : Recombinant fragment of Human MYO1A with N-terminal proprietary tag. Predicted MW 36.63kDa.
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  • Gene Information
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Description : The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding neck region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein encoded by this gene envelops an actin core bundle that, by comparison, is static in structure.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : SVTSLKDGLFSLHLSEMSSVGSKGD FLLVSEHVIELLTKMYRAVLDATQR QLTVTVTEKFSVRFKENSVAVKVVQ GPAGGDNSKLRYKKKGSHCLEVTVQ
Sequence Similarities : Contains 3 IQ domains.Contains 1 myosin head-like domain.
Gene Name : MYO1A myosin IA [ Homo sapiens ]
Official Symbol : MYO1A
Synonyms : MYO1A; myosin IA; DFNA48, MYHL; myosin-Ia;
Gene ID : 4640
mRNA Refseq : NM_005379
Protein Refseq : NP_005370
MIM : 601478
Uniprot ID : Q9UBC5
Chromosome Location : 12q13-q15
Function : ATP binding; actin binding; calmodulin binding; motor activity; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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