Recombinant Human NCF2

• Cat.No.: NCF2-30174TH
• Product Overview: Recombinant full length Human NOXA2/p67phox with N-terminal proprietary tag; 83.86 kDa.

Specification

• Description: This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Protein length: 526 amino acids
• Molecular Weight: 83.860kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRIC FNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGML YYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKID KAMECVWKQKLYEPVVIPVGRLFRPNERQVAQLAKKDYLG KATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATV MFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAP PSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY TVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSN ELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPK ESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLE STRREV
• Sequence Similarities: Belongs to the NCF2/NOXA1 family.Contains 1 OPR domain.Contains 2 SH3 domains.Contains 3 TPR repeats.

Gene Information

• Gene Name: NCF2 neutrophil cytosolic factor 2 [ Homo sapiens ]
• Official Symbol: NCF2
• Synonyms: NCF2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); neutrophil cytosol factor 2; chronic granulomatous disease; autosomal 2; NADPH oxidase activator 2; NOXA2; p67phox
• Gene ID: 4688
• mRNA Refseq: NM_000433
• Protein Refseq: NP_000424
• MIM: 608515
• Uniprot ID: P19878
• Chromosome Location: 1q25
• Pathway: Leishmaniasis, organism-specific biosystem; Leishmaniasis, conserved biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; Osteoclast differentiation, organism-specific biosystem
• Function: Rac GTPase binding; electron carrier activity; protein C-terminus binding; protein binding; superoxide-generating NADPH oxidase activity