Recombinant Human NFKBIB

• Cat.No.: NFKBIB-29577TH
• Product Overview: Recombinant full length human IKB beta with an N-terminal proprietary tag; amino acids 1-336, 56kDa.

Specification

• Description: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Tissue specificity: Expressed in all tissues examined.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: Purity was determined to be >90% by densitometry.
• Sequence Similarities: Belongs to the NF-kappa-B inhibitor family.Contains 6 ANK repeats.

Gene Information

• Gene Name: NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [ Homo sapiens ]
• Official Symbol: NFKBIB
• Synonyms: NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; NF-kappa-B inhibitor beta; IKBB; TRIP9
• Gene ID: 4793
• mRNA Refseq: NM_001243116
• Protein Refseq: NP_001230045
• MIM: 604495
• Uniprot ID: Q15653
• Chromosome Location: 19q13.1
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem
• Function: protein binding; signal transducer activity; transcription coactivator activity