Recombinant Human SERPINI1 protein
Cat.No. : | SERPINI1-1670H |
Product Overview : | Recombinant Human SERPINI1 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Description : | Neuroserpin encoded by the SERPINI1 gene in humans is a member of the serine proteinase inhibitor (serpin) family. It reacts preferentially with tissue-type plasminogen activator (tPA). Neuroserpin is expressed mainly in the central nervous system (CNS) in response to neuronal depolarization and plays an important role in the development of synaptic plasticity. Mutations in human neuroserpin result in a form of autosomal dominant inherited dementia which is characterized by the presence of intraneuronal inclusion bodies and is known as Familial Encephalopathy with Neuroserpin Inclusion Bodies. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5 μg/ml, corresponding to a specific activity of > 2000 IU/mg. |
Molecular Mass : | Approximately 44.7 kDa, a single non-glycosylated polypeptide chain containing 394 amino acid residues. |
Protein length : | 394 |
AA Sequence : | TGATFPEEAIADLSVNMYNRLRATG EDENILFSPLSIALAMGMMELGAQG STQKEIRHSMGYDSLKNGEEFSFLK EFSNMVTAKESQYVMKIANSLFVQN GFHVNEEFLQMMKKYFNAAVNHVDF SQNVAVANYINKWVENNTNNLVKDL VSPRDFDAATYLALINAVYFKGNWK SQFRPENTRTFSFTKDDESEVQIPM MYQQGEFYYGEFSDGSNEAGGIYQV LEIPYEGDEISMMLVLSRQEVPLAT LEPLVKAQLVEEWANSVKKQKVEVY LPRFTVEQEIDLKDVLKALGITEIF IKDANLTGLSDNKEIFLSKAIHKSF LEVNEEGSEAAAVSGMIAISRMAVL YPQVIVDHPFFFLIRNRRTGTILFM GRVMHPETMNTSGHDFEEL |
Endotoxin : | Less than 1 EU/μg of rHuNeuroserpin as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | SERPINI1 |
Official Symbol : | SERPINI1 |
Synonyms : | SERPINI1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; PI12, serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; PI12; DKFZp781N13156; |
Gene ID : | 5274 |
mRNA Refseq : | NM_001122752 |
Protein Refseq : | NP_001116224 |
MIM : | 602445 |
UniProt ID : | Q99574 |
Products Types
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SERPINI1-3973R | Recombinant Rhesus Macaque SERPINI1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SERPINI1-01H | Active Recombinant Human SERPINI1 Protein, GST-tagged | +Inquiry |
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◆ Lysates | ||
SERPINI1-1658MCL | Recombinant Mouse SERPINI1 cell lysate | +Inquiry |
SERPINI1-2566HCL | Recombinant Human SERPINI1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSERPINI1 proteins may play different roles in the prognosis of different neurological diseases, and further research will help us better understand their specific role in prognosis
Because of its role in neurological disorders, SERPINI1 protein is thought to be a potential target for the treatment of these diseases. However, more research is needed to verify its feasibility.
In some cases, mutations in SERPINI1 proteins can lead to problems with nerve cell connectivity, affecting the normal function of the nervous system, leading to neurological disorders.
Research on SERPINI1 protein is still in its infancy, so there is no specific drug needle to treat it.
SERPINI1 proteins are mainly involved in synaptic breeding and the formation of neuronal connections in nerve cells, and play an important role in the normal function of the nervous system.
Commonly used methods include immunohistochemistry, western blotting, and immunohistochemical staining.
Customer Reviews (3)
Write a reviewIt has strong specificity and selectivity for the target of action, which is suitable for experiments.
The effect is good and has a significant effect on cell growth and proliferation.
Good crystallinity, suitable for crystallography research.
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