Recombinant Human NR4A1

• Cat.No.: NR4A1-28049TH
• Product Overview: Recombinant full length Human NUR77 with N terminal proprietary tag; Predicted MWt 91.89 kDa.

Specification

• Description: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 598 amino acids
• Molecular Weight: 91.890kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Fetal muscle and adult liver, brain and thyroid.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASP EAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSS ASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGH FSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSP SLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYG VRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQ FCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDA GDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLE SAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQE PRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLP ELRTLCTRGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR4 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Gene Information

• Gene Name: NR4A1 nuclear receptor subfamily 4, group A, member 1 [ Homo sapiens ]
• Official Symbol: NR4A1
• Synonyms: NR4A1; nuclear receptor subfamily 4, group A, member 1; GFRP1, HMR; nuclear receptor subfamily 4 group A member 1; N10; NAK 1; NGFIB; NUR77; TR3
• Gene ID: 3164
• mRNA Refseq: NM_001202233
• Protein Refseq: NP_001189162
• MIM: 139139
• Uniprot ID: P22736
• Chromosome Location: 12q13
• Pathway: AKT phosphorylates targets in the nucleus, organism-specific biosystem; Downstream signal transduction, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; GAB1 signalosome, organism-specific biosystem; Gene Expression, organism-specific biosystem
• Function: DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ligand-dependent nuclear receptor activity; ligand-dependent nuclear receptor activi