Recombinant Human NR5A1

• Cat.No.: NR5A1-31465TH
• Product Overview: Recombinant full length Human Steroidogenic Factor 1 with N terminal proprietary tag; Predicted MWt 76.78 kDa.

Specification

• Description: The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect.
• Protein length: 461 amino acids
• Molecular Weight: 76.780kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRT VQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRL EAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL ETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGP LGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEP YASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQV RARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWA RRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKE GSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLA LQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAA LLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHK HLGNEMPRNNLLIEMLQAKQT
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR5 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Gene Information

• Gene Name: NR5A1 nuclear receptor subfamily 5, group A, member 1 [ Homo sapiens ]
• Official Symbol: NR5A1
• Synonyms: NR5A1; nuclear receptor subfamily 5, group A, member 1; FTZF1; steroidogenic factor 1; AD4BP; ELP; FTZ1; SF 1
• Gene ID: 2516
• mRNA Refseq: NM_004959
• Protein Refseq: NP_004950
• Uniprot ID: Q13285
• Chromosome Location: 9q33
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem
• Function: DNA binding; chromatin binding; double-stranded DNA binding; enzyme binding; ligand-dependent nuclear receptor activity