Recombinant Human PARP3, GST-tagged
Cat.No. : | PARP3-27634TH |
Product Overview : | Recombinant full length Human PARP3 with N terminal GST-tag expressed in a Baculovirus infected Sf9 cell expression system, 87 kDa. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Conjugation : | GST |
Tissue specificity : | Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus. |
Biological activity : | Specific Activity: 207.5 U/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Contains 1 PARP alpha-helical domain.Contains 1 PARP catalytic domain. |
Gene Name : | PARP3 poly (ADP-ribose) polymerase family, member 3 [ Homo sapiens ] |
Official Symbol : | PARP3 |
Synonyms : | PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase |
Gene ID : | 10039 |
mRNA Refseq : | NM_001003931 |
Protein Refseq : | NP_001003931 |
MIM : | 607726 |
Uniprot ID : | Q9Y6F1 |
Chromosome Location : | 3p22.2-p21.1 |
Pathway : | BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; |
Function : | NAD+ ADP-ribosyltransferase activity; catalytic activity; transferase activity, transferring glycosyl groups; |
Products Types
◆ Recombinant Protein | ||
PARP3-642H | Recombinant Human PARP3 Protein, His-tagged | +Inquiry |
PARP3-432H | Recombinant Human PARP3 Protein, MYC/DDK-tagged | +Inquiry |
Parp3-4679M | Recombinant Mouse Parp3 Protein, Myc/DDK-tagged | +Inquiry |
PARP3-434H | Recombinant Human Poly (ADP-ribose) Polymerase 3, GST-tagged | +Inquiry |
PARP3-454H | Active Recombinant Human PARP3, HA-tagged | +Inquiry |
◆ Lysates | ||
PARP3-525HCL | Recombinant Human PARP3 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1802 | PARP3 Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPARP3 interacts with various proteins involved in DNA repair, forming complexes that coordinate the repair process.
Dysregulation of PARP3 can lead to genomic instability and impaired DNA repair, contributing to the development and progression of certain cancers.
While there are research tools for studying PARP3 activity in the laboratory, clinical diagnostic tools targeting PARP3 are still in the early stages of development.
Emerging research suggests that PARP3 may play a role in immune regulation, and its modulation could potentially impact immune responses in diseases such as cancer.
Some clinical trials are exploring the efficacy and safety of PARP inhibitors, and their potential application in cancers where PARP3 is implicated.
Customer Reviews (3)
Write a reviewAn additional advantage of selecting the PARP3 protein is the outstanding technical support offered by its manufacturer.
Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.
The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.
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