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Recombinant Human PARP3, GST-tagged

Cat.No. : PARP3-27634TH
Product Overview : Recombinant full length Human PARP3 with N terminal GST-tag expressed in a Baculovirus infected Sf9 cell expression system, 87 kDa.
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  • Gene Information
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Description : The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
Conjugation : GST
Tissue specificity : Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Biological activity : Specific Activity: 207.5 U/mg.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Contains 1 PARP alpha-helical domain.Contains 1 PARP catalytic domain.
Gene Name : PARP3 poly (ADP-ribose) polymerase family, member 3 [ Homo sapiens ]
Official Symbol : PARP3
Synonyms : PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase
Gene ID : 10039
mRNA Refseq : NM_001003931
Protein Refseq : NP_001003931
MIM : 607726
Uniprot ID : Q9Y6F1
Chromosome Location : 3p22.2-p21.1
Pathway : BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;
Function : NAD+ ADP-ribosyltransferase activity; catalytic activity; transferase activity, transferring glycosyl groups;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PARP3 interact with other proteins in the DNA repair pathway? 03/26/2023

PARP3 interacts with various proteins involved in DNA repair, forming complexes that coordinate the repair process.

How does the dysregulation of PARP3 relate to cancer development? 12/12/2019

Dysregulation of PARP3 can lead to genomic instability and impaired DNA repair, contributing to the development and progression of certain cancers.

Are there any diagnostic tools specifically detecting PARP3 activity? 03/09/2018

While there are research tools for studying PARP3 activity in the laboratory, clinical diagnostic tools targeting PARP3 are still in the early stages of development.

Is PARP3 involved in the regulation of immune responses? 02/05/2018

Emerging research suggests that PARP3 may play a role in immune regulation, and its modulation could potentially impact immune responses in diseases such as cancer.

Are there any clinical trials involving PARP3 inhibitors? 09/09/2016

Some clinical trials are exploring the efficacy and safety of PARP inhibitors, and their potential application in cancers where PARP3 is implicated.

Customer Reviews (3)

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Reviews
01/25/2023

    An additional advantage of selecting the PARP3 protein is the outstanding technical support offered by its manufacturer.

    09/09/2019

      Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.

      01/13/2016

        The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.

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