Recombinant Human PCM1

• Cat.No.: PCM1-30551TH
• Product Overview: Recombinant full length Human PCM1 with N terminal proprietary tag, predicted mwt: 84.41 kDa.

Specification

• Description: The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
• Protein length: 530 amino acids
• Molecular Weight: 84.410kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKK ANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTP HTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSD SQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSP PNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT HLIDHLKEQEKSYMKFLKKILARENEEEDVRTIDSAVGSG SVAESTSLNIDVQSEASDTTARDPQQEPMEEIENLKKQHD LLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSV VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAV PDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMR VLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRST SAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENE GHLNPSEKLQ
• Sequence Similarities: Belongs to the PCM1 family.

Gene Information

• Gene Name: PCM1 pericentriolar material 1 [ Homo sapiens ]
• Official Symbol: PCM1
• Synonyms: PCM1; pericentriolar material 1; pericentriolar material 1 protein; PTC4
• Gene ID: 5108
• mRNA Refseq: NM_006197
• Protein Refseq: NP_006188
• MIM: 600299
• Uniprot ID: Q15154
• Chromosome Location: 8p22-p21.3
• Pathway: Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem
• Function: identical protein binding; protein binding