Recombinant Human PDE1B

• Cat.No.: PDE1B-29995TH
• Product Overview: Recombinant Full Length Human PDE1B,, with N terminal enzyme tag. MW= 87 kDa. Expressed in a Baculovirus infected Sf9 cell expression system.

Specification

• Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 20mM Glutathione, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Gene Information

• Gene Name: PDE1B phosphodiesterase 1B, calmodulin-dependent [ Homo sapiens ]
• Official Symbol: PDE1B
• Synonyms: PDE1B; phosphodiesterase 1B, calmodulin-dependent; PDES1B; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B
• Gene ID: 5153
• mRNA Refseq: NM_000924
• Protein Refseq: NP_000915
• MIM: 171891
• Uniprot ID: Q01064
• Chromosome Location: 12q13
• Pathway: Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Calmodulin induced events, organism-specific biosystem
• Function: 3,5-cyclic-AMP phosphodiesterase activity; calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity