Recombinant Human PDE4C

• Cat.No.: PDE4C-30820TH
• Product Overview: Recombinant full length Human PDE4C protein with N-terminal proprietary tag, expressed in a Baculovirus infected Sf9 cell expression system, 106 kDa.

Specification

• Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Biological activity: Specific Activity: 17230 pmol/min/μg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: PDE4C phosphodiesterase 4C, cAMP-specific [ Homo sapiens ]
• Official Symbol: PDE4C
• Synonyms: PDE4C; phosphodiesterase 4C, cAMP-specific; DPDE1, phosphodiesterase 4C, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E1); cAMP-specific 3,5-cyclic phosphodiesterase 4C; phosphodiesterase E1 dunce homolog (Drosophila)
• Gene ID: 5143
• mRNA Refseq: NM_000923
• Protein Refseq: NP_000914
• MIM: 600128
• Uniprot ID: Q08493
• Chromosome Location: 19p13.11
• Pathway: DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Opioid Signalling, organism-specific biosystem
• Function: 3,5-cyclic-AMP phosphodiesterase activity; drug binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity