Recombinant Human PDHA1 protein, His-tagged
Cat.No. : | PDHA1-28668TH |
Product Overview : | Recombinant Human PDHA1 fussed with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilised. 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5. |
AA Sequence : | MRKMLAAVSRVLSGASQKPASRVLV ASRNFANDATFEIKKCDLHRLEEGP PVT TVLTREDGLKYYRMMQTVRRMELKA DQLYKQKIIRGFCHLCDGQE ACCVGLEA GINPTDHLITAYRAHGFTFTRGLSV REILAELTGRKGGCA KGKGGSMHMYAKN FYGGNGIVGAQVPLGAGIALACKYN GKDEVCLTLY GDGAANQGQIFEAYNMAA LWKLPCIFICENNRYGMGTSVERAA ASTDY YKRGDFIPGLRVDGMDILCVREA TRFAAAYCRSGKGPILMELQTYRYH GHSMSDPGVSYRTREEIQEVRSKSD PIM LLKDRMVNSNLASVEELKEI DVEVRKEIEDAAQFATADPEPPLEE LGYHIYSS DPPFEVRGANQWIKF KSVS |
Applications : | Western blot; Mass Spectrometry; SDS-PAGE |
Stability : | Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
Reconstitution : | Reconstitute with 160 µl aqua dest. |
Gene Name : | PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 [ Homo sapiens ] |
Official Symbol : | PDHA1 |
Synonyms : | PDHA; PDHAD; PHE1A; PDHCE1A; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; pyruvate dehydrogenase E1 subunit; pyruvate dehydrogenase complex, E1-alpha polypeptide 1 |
Gene ID : | 5160 |
mRNA Refseq : | NM_000284 |
Protein Refseq : | NP_000275 |
MIM : | 300502 |
UniProt ID : | P08559 |
Chromosome Location : | Xp22.1 |
Pathway : | Acetylcholine Synthesis, organism-specific biosystem; Biosynthesis of antibiotics, organism-specific biosystem; Central carbon metabolism in cancer, organism-specific biosystem |
Function : | pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity |
Products Types
◆ Recombinant Protein | ||
PDHA1-825H | Recombinant Human PDHA1 Protein, MYC/DDK-tagged | +Inquiry |
PDHA1-1635H | Recombinant Human PDHA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PDHA1-6598M | Recombinant Mouse PDHA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pdha1-4760M | Recombinant Mouse Pdha1 Protein, Myc/DDK-tagged | +Inquiry |
PDHA1-3173R | Recombinant Rhesus Macaque PDHA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PDHA1-001HCL | Recombinant Human PDHA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket