Recombinant Human PHB

• Cat.No.: PHB-29709TH
• Product Overview: Recombinant full length Human Prohibitin with an N terminal proprietary tag; Predicted MWt 55.66 kDa inclusive of tag.

Specification

• Description: Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed.It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor.Mutations in PHB have been linked to sporadic breast cancer.Prohibitin is expressed as two transcripts with varying lengths of 3 untranslated region.The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3 untranslated region may function as a trans-acting regulatory RNA.
• Protein length: 272 amino acids
• Molecular Weight: 55.660kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Widely expressed in different tissues.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVVFD RFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVIT GSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLP SITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVV EKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRK LEAAGDIAYQLSRSRNITYLPAGQSVLLQLPQ
• Sequence Similarities: Belongs to the prohibitin family.

Gene Information

• Gene Name: PHB prohibitin [ Homo sapiens ]
• Official Symbol: PHB
• Synonyms: PHB; prohibitin; PHB1
• Gene ID: 5245
• mRNA Refseq: NM_002634
• Protein Refseq: NP_002625
• MIM: 176705
• Uniprot ID: P35232
• Chromosome Location: 17q21
• Function: histone deacetylase binding; protein binding; transcription regulatory region DNA binding