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Native Human Human SERPINE1

Cat.No. : PLAU-31777TH
Product Overview : Full length Human PAI1 reacted with full length Human PLAU; MWt 97 kDa.
  • Specification
  • Gene Information
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Description : This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimers disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 0.1M Sodium chloride, 0.1M HEPES, pH 7.4
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : PLAU plasminogen activator, urokinase [ Homo sapiens ]
Official Symbol : PLAU
Synonyms : PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK;
Gene ID : 5328
mRNA Refseq : NM_001145031
Protein Refseq : NP_001138503
MIM : 191840
Uniprot ID : P00749
Chromosome Location : 10q24
Pathway : ATF-2 transcription factor network, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem;
Function : peptidase activity; protein binding; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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