Native Human PLG

• Cat.No.: PLG-27842TH
• Product Overview: Full length Human Plasmin purified from Human Plasma, MWt 81kDa.

Specification

• Description: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
• Biological activity: Activity: One unit is defined as the amount of enzyme that hydrolyzes one μmole of tosyl-Gly-Pro-Lys-pNA per minute at 25°C, pH 7.8. Note: One unit = 1.25 CU.
• Form: Lyophilised
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10mg/ml Sodium chloride, 10mg/ml D-Mannitol, 20mM Sodium phosphate, pH 7.4
• Storage: Shipped at 4°C. Store at -20oC.

Gene Information

• Gene Name: PLG plasminogen [ Homo sapiens ]
• Official Symbol: PLG
• Synonyms: PLG; plasminogen
• Gene ID: 5340
• mRNA Refseq: NM_000301
• Protein Refseq: NP_000292
• MIM: 173350
• Uniprot ID: P00747
• Chromosome Location: 6q26
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: apolipoprotein binding; cell surface binding; endopeptidase activity; peptidase activity; protein binding