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Recombinant Human CARM1

Cat.No. : CARM1-451H
Product Overview : Recombinant Human PRMT4, amino-acids 2-end expressed in aFreeStyle 293-F cellsexpression system. MW= 66 kDa.
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  • Gene Information
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Cat. No. : CARM1-451H
Description : CARM1 (coactivator-associated arginine methyltransferase 1) is an enzyme encoded by the CARM1 gene found in human beings, as well as many other mammals. CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts. This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.
Source : FreeStyle 293-F cells.
Purity : >60%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
Stability : >6 months at –80°C.
Gene Name : CARM1 coactivator-associated arginine methyltransferase 1 [ Homo sapiens ]
Synonyms : CARM1; coactivator-associated arginine methyltransferase 1; PRMT4;EC 2.1.1.125; 3` partial; protein arginine N-methyltransferase 4; Histone-arginine methyltransferase CARM1;EC2.1.1.-; Protein arginine N-methyltransferase 4; Coactivator-associated arginine methyltransferase 1
Gene ID : 10498
mRNA Refseq : NM_199141
Protein Refseq : NP_954592
MIM : 603934
UniProt ID : Q86X55
Chromosome Location : 19p13.2
Pathway : Metabolism of lipids and lipoproteins
Function : histone-arginine N-methyltransferase activity; transferase activity; protein binding; transcription coactivator activity; protein methyltransferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CARM1 contribute to the DNA damage response and repair mechanisms? 01/22/2022

CARM1 is involved in the DNA damage response by influencing the recruitment of repair factors to damaged sites. Its role in chromatin remodeling contributes to efficient DNA repair processes.

Discuss the role of CARM1 in epigenetic regulation and its impact on cellular differentiation. 10/09/2021

CARM1 contributes to epigenetic regulation by modifying histones, promoting chromatin accessibility, and influencing the differentiation of cells by regulating the expression of lineage-specific genes.

What are the specific substrates of CARM1, and how does its methylation activity impact cellular processes? 02/13/2020

CARM1 methylates arginine residues in histones, transcription factors, and other regulatory proteins. This modification regulates chromatin dynamics, transcriptional activation, and mRNA splicing.

How does CARM1 contribute to gene regulation at the molecular level? 06/27/2019

CARM1 acts as a coactivator by methylating histone and non-histone proteins, modulating chromatin structure, and influencing gene expression through its involvement in transcriptional regulation.

Explain the interplay between CARM1 and other chromatin-modifying enzymes in the regulation of gene expression. 04/08/2018

CARM1 collaborates with histone acetyltransferases and other methyltransferases to modulate chromatin structure and transcription. This interplay is crucial for the fine-tuning of gene expression.

Customer Reviews (3)

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Reviews
09/29/2021

    Expert advice from customer service ensured we made the right protein choice.

    03/12/2020

      Fast and reliable delivery made a significant impact on our project timelines.

      07/26/2018

        Seamless service experience—this product was a breeze to order and receive.

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