Recombinant Human PPARG, His-tagged
Cat.No. : | PPARG-30104TH |
Product Overview : | Recombinant full length Human PPAR gamma with an amino-terminal hexahistidine tag |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. |
Conjugation : | HIS |
Source : | E. coli |
Tissue specificity : | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 20mM Tris, pH 8 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. |
Gene Name : | PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ] |
Official Symbol : | PPARG |
Synonyms : | PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma; |
Gene ID : | 5468 |
mRNA Refseq : | NM_005037 |
Protein Refseq : | NP_005028 |
MIM : | 601487 |
Uniprot ID : | P37231 |
Chromosome Location : | 3p25 |
Pathway : | Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; |
Function : | DNA binding; activating transcription factor binding; arachidonic acid binding; drug binding; enzyme binding; |
Products Types
◆ Recombinant Protein | ||
PPARG-3355R | Recombinant Rhesus Macaque PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
PPARG-4935H | Recombinant Human PPARG Protein, His-tagged | +Inquiry |
PPARG-0777H | Recombinant Human PPARG Protein (P234-Y505), Tag Free | +Inquiry |
PPARG-547C | Recombinant Cynomolgus Monkey PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
PPARG-4253R | Recombinant Rat PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PPARG-492HCL | Recombinant Human PPARG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionPPARG has two isoforms, PPARG1 (57 kDa) and PPARG2, a splice variant with an additional 30 amino acids at the N-terminus.
PPARG has two isoforms with molecular weights of 57 kDa and 54 kDa. Modified PPARG is about 67 kDa.
PPARG stands for Peroxisome Proliferator-Activated Receptor Gamma.
Yes, experimental data suggests a 45 kDa protein immunologically related to PPARG, called mt-PPAR, is located in mitochondria. Its molecular weight is less than PPARG2.
PPARG is a ligand-activated transcription factor that plays a crucial role in regulating lipid homeostasis, adipogenesis, insulin resistance, and organ development.
Defects in PPARG are associated with familial partial lipodystrophy type 3 (FPLD3), susceptibility to obesity, type 2 insulin-resistant diabetes, hypertension, and colon cancer.
PPARG is mainly localized in the nucleus, although it can also be detected in the cytoplasm, exhibiting extra-nuclear/non-genomic actions in certain contexts.
Customer Reviews (3)
Write a reviewIt was reassuring to use a product that adhered to green chemistry principles, reducing our impact on the environment.
The company's dedication to environmental sustainability reflected positively on the product and our research initiatives.
We appreciated the option to request modifications or custom formulations to meet our project's requirements.
Ask a Question for All PPARG Products
Required fields are marked with *
My Review for All PPARG Products
Required fields are marked with *
Inquiry Basket