Recombinant Human PRDM2

• Cat.No.: PRDM2-27746TH
• Product Overview: Recombinant fragment corresponding to amino acids 2-200 of Human KMT8/Riz1/Riz2 with N-terminal proprietary tag, 48.6 kDa.

Specification

• Description: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Tissue specificity: Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
• Biological activity: Specific Activity: 0.15 pmol/min/μg.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 8 C2H2-type zinc fingers.Contains 1 SET domain.

Gene Information

• Gene Name: PRDM2 PR domain containing 2, with ZNF domain [ Homo sapiens ]
• Official Symbol: PRDM2
• Synonyms: PRDM2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; GATA 3 binding protein G3B; HUMHOXY1; KMT8; MTB ZF; MTE binding protein; retinoblastoma protein binding zinc finger protein; retinoblastoma protein interacting zinc finger pr
• Gene ID: 7799
• mRNA Refseq: NM_001007257
• Protein Refseq: NP_001007258
• MIM: 601196
• Uniprot ID: Q13029
• Chromosome Location: 1p36
• Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; sequence-specific DNA binding transcription factor activity