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Recombinant Human PRDX2, His-tagged

Cat.No. : PRDX2-29680TH
Product Overview : Recombinant full length Human Peroxiredoxin 2 with N-terminal His tag expressed in a Baculovirus infected Sf9 cell expression system, 22.7 kDa.
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  • Gene Information
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Description : This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.
Conjugation : HIS
Biological activity : Specific Activity: 149 pmol/min/μg.3.45 μg of Peroxiredoxin 2 was incubated in 50 mM Hepes (pH 7.0) containing 200 μM NADPH, 3 μM thioredoxin, and 1.5 μM thioredoxin reductase. The reaction mixture was incubated at 30C for 5 min, followed by the addition
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the ahpC/TSA family.Contains 1 thioredoxin domain.
Gene Name : PRDX2 peroxiredoxin 2 [ Homo sapiens ]
Official Symbol : PRDX2
Synonyms : PRDX2; peroxiredoxin 2; TDPX1; peroxiredoxin-2; MGC4104; natural killer enhancing factor B; NKEFB; PRP; PRX2; PRXII; thiol specific antioxidant 1; thioredoxin peroxidase 1; thioredoxin dependent peroxide reductase 1; torin; TSA;
Gene ID : 7001
mRNA Refseq : NM_005809
Protein Refseq : NP_005800
MIM : 600538
Uniprot ID : P32119
Chromosome Location : 19p13.2
Pathway : Selenium Pathway, organism-specific biosystem;
Function : antioxidant activity; antioxidant activity; oxidoreductase activity; thioredoxin peroxidase activity; thioredoxin peroxidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PRDX2 contribute to the field of cancer research and treatment? 04/25/2021

PRDX2's role in maintaining cellular redox balance implicates it in cancer progression. Modulating PRDX2 levels may offer avenues for developing novel cancer therapies.

Are there any side effects associated with targeting PRDX2 for therapeutic purposes? 02/11/2021

As with any targeted therapy, potential side effects need thorough investigation. Modulating PRDX2 levels could impact normal cellular functions, and careful assessment is required.

Is there evidence supporting the use of PRDX2 as a prognostic marker in certain diseases? 08/26/2020

Some studies suggest that PRDX2 levels may have prognostic value in diseases associated with oxidative stress, providing insights into disease progression.

Can PRDX2 be a target for drug development, and what challenges might be associated with this? 03/23/2018

Yes, PRDX2 is a potential drug target, but challenges include developing specific modulators and understanding the protein's complex regulatory mechanisms.

Are there any specific diagnostic tests or biomarkers related to PRDX2 protein levels? 08/22/2017

Research suggests that altered levels of PRDX2 could serve as a biomarker in diseases associated with oxidative stress, offering potential diagnostic applications.

Customer Reviews (3)

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Reviews
02/01/2022

    I am eager to embark on this scientific journey, empowered by the high-quality PRDX2 protein and the manufacturer's unparalleled assistance.

    12/16/2020

      The manufacturer's prompt and reliable technical support serves as an invaluable resource, reinforcing my confidence in the PRDX2 protein's effectiveness and enabling smooth progress in my experiments.

      11/01/2017

        Its remarkable purity and functional attributes make it an optimal choice for my research, ensuring accurate and reliable outcomes.

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