Recombinant Human DYRK2, His-tagged

• Cat.No.: DYRK2-518H
• Product Overview: Recombinant Human DYRK2 (full length) was expressed in aBaculovirus infected Sf9cell expression system with N-terminal His tag. MW=63.5 kDa.

Specification

• Cat. No.: DYRK2-518H
• Description: Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme that in humans is encoded by the DYRK2 gene. DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5" terminal insert.
• Source: Sf9.
• Formulated In: 25mM Tris-HCl, pH 7.5, 100mM NaCl, 0.05% Tween 20, 10% glycerol and 3mM DTT.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Purity: > 50%.
• Stability: >12 months at –80°C.

Gene Information

• Gene Name: DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [ Homo sapiens ]
• Synonyms: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; FLJ21217; FLJ21365; DYRK2; EC 2.7.12.1
• Gene ID: 8445
• mRNA Refseq: NM_003583
• Protein Refseq: NP_003574
• MIM: 603496
• UniProt ID: Q92630
• Chromosome Location: 12q15
• Function: ATP binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity