Active Native Human PRSS1

• Cat.No.: PRSS1-30745TH
• Product Overview: Full length native mature Trypsin from human pancreas.

Specification

• Description: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
• Source: human pancreas
• Species: Human
• Form: Lyophilised:Reconstitute in 56.5μl 2mM HCl. Use product immediately after bringing to neutral pH to avoid auto-degradation.After reconstitution, aliquot and store at -20oC.Avoid multiple freeze/thaw cycles.
• Bio-activity: Activity: >2.5units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one umole of N-Benzyl-L-arginine-pNA per minute at 25oC in 200mM Tris-HCl, pH 7.8, 20mM CaCl2.
• Purity: >95% by SDS-PAGE
• Storage: Store at -20°C . Stable for 12 months at -20°C
• Storage Buffer: Preservative: None

Gene Information

• Gene Name: PRSS1 protease, serine, 1 (trypsin 1) [ Homo sapiens ]
• Official Symbol: PRSS1
• Synonyms: PRSS1; protease, serine, 1 (trypsin 1); TRY1; trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1; TRP1; TRY4; TRYP1; FLJ57296; MGC120175; MGC149362; DKFZp779A0837
• Gene ID: 5644
• mRNA Refseq: NM_002769
• Protein Refseq: NP_002760
• MIM: 276000
• UniProt ID: P07477
• Chromosome Location: 7q34
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem
• Function: metal ion binding; peptidase activity; serine-type endopeptidase activity