Active Recombinant Human PTPN11 protein, GST-tagged
Cat.No. : | PTPN11-31402TH |
Product Overview : | Recombinant Human PTPN11(224–529 aa) fused with GST tag at N-terminal was expressed in E. coli. |
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Description : | Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione. |
Bio-activity : | 10 U/µg |
Molecular Mass : | 62 kDa |
AA Sequence : | MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLVPRG SASAEIESRVRELSKLAETTDKVKQ GFWEEFETLQQQECKLLYSRKEGQR QENKNKNRYKNILPFDHTRVVLHDG DPNEPVSDYINANIIMPEFETKCNN SKPKKSYIATQGCLQNTVNDFWRMV FQENSRVIVMTTKEVERGKSKCVKY WPDEYALKEYGVMRVRNVKESAAHD YTLRELKLSKVGQGNTERTVWQYHF RTWPDHGVPSDPGGVLDFLEEVHHK QESIMDAGPVVVHCSAGIGRTGTFI VIDILIDIIREKGVDCDIDVPKTIQ MVRSQRSGMVQTEAQYRFIYMAVQH YIETLQRRILE |
Purity : | > 90% |
Unit Definition : | One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30 centigrade. |
Applications : | Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors. |
Storage : | >12 months at -80 centigrade. Avoid freeze/thaw cycles. |
Concentration : | 0.73 mg/ml |
Publication : |
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor (2017)
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Gene Name : | PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ] |
Official Symbol : | PTPN11 |
Synonyms : | PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433; |
Gene ID : | 5781 |
mRNA Refseq : | NM_002834 |
Protein Refseq : | NP_002825 |
MIM : | 176876 |
UniProt ID : | Q06124 |
Chromosome Location : | 12q24.1 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; |
Function : | hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity; |
Products Types
◆ Recombinant Protein | ||
PTPN11-4489R | Recombinant Rat PTPN11 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN11-04H | Active Recombinant Human PTPN11 Protein(Full length), N-GST-tagged | +Inquiry |
PTPN11-18H | Active Recombinant Human PTPN11 Protein, N-terminal 6XHis and AviTag™, Biotinylated | +Inquiry |
Ptpn11-5235M | Recombinant Mouse Ptpn11 Protein, Myc/DDK-tagged | +Inquiry |
Ptpn11-8674M | Active Recombinant Mouse Ptpn11 protein(Met1-Arg593), His-tagged | +Inquiry |
◆ Lysates | ||
PTPN11-1334MCL | Recombinant Mouse PTPN11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, genetic testing can identify mutations in the PTPN11 gene, providing valuable information for diagnosis and treatment planning.
PTPN11 is involved in various signaling pathways, including the RAS-MAPK pathway, and its mutations can dysregulate these pathways, leading to abnormal cell signaling.
Yes, PTPN11 plays a crucial role in normal cellular functions by regulating the activity of proteins through dephosphorylation.
Yes, the presence of PTPN11 mutations can serve as a biomarker for specific cancers and developmental disorders.
Mutations in PTPN11 can lead to developmental disorders, including Noonan syndrome and LEOPARD syndrome, affecting growth and development.
Customer Reviews (3)
Write a reviewTheir technical expertise and knowledge of the PTPN11 protein are invaluable resources.
This reliability reduces experimental variability and enhances the accuracy of data interpretation.
the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in PTPN11 protein research.
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