Recombinant Mouse FMS-like Tyrosine Kinase 4
Cat.No. : | Flt4-1787M |
- Specification
- Gene Information
- Related Products
Cat. No. : | Flt4-1787M |
Description : | Vascular endothelial growth factor receptor 3 (VEGF R3) is one of the five receptor tyrosine kinases whose expression is almost exclusively restricted to endothelial cells of the lymphatic system. VEGF R3 is a specific marker for lymphatic vessels. It has also been detected on some high endothelial venules, in embryonic prelymphatic blood vessels, in some tumor blood vessels, and in certain hematopoietic and leukemia cells. The predominant role of VEGF-R3 is its involvement in the development of the lymphatic vessel system. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse VEGF R3 is Mr 84.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 133 kDa. |
Source : | Sf 21 Insect Cells. |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Flt4 FMS-like tyrosine kinase 4 [ Mus musculus ] |
Synonyms : | Flt4; FMS-like tyrosine kinase 4; Chy; Flt-4; VEGFR3; VEGFR-3; AI323512; chylous ascites; OTTMUSP00000005713; receptor protein tyrosine kinase; vascular endothelial growth factor receptor-3; EC 2.7.10.1 |
Gene ID : | 14257 |
mRNA Refseq : | NM_008029 |
Protein Refseq : | NP_032055 |
UniProt ID : | P35917 |
Chromosome Location : | 11 A5-B1; 11 25.0 cM |
Pathway : | Cytokine-cytokine receptor interaction; Focal adhesion |
Function : | ATP binding; growth factor binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity |
Products Types
◆ Recombinant Protein | ||
FLT4-4379H | Recombinant Human FLT4 Protein, GST-tagged | +Inquiry |
FLT4-2021R | Recombinant Rat FLT4 Protein, His (Fc)-Avi-tagged | +Inquiry |
FLT4-4413H | Recombinant Human FLT4 Protein, His (Fc)-Avi-tagged | +Inquiry |
FLT4-478H | Recombinant Human FLT4 Protein, Fc-tagged | +Inquiry |
FLT4-101H | Recombinant Human FLT4 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
FLT4-2709HCL | Recombinant Human FLT4 cell lysate | +Inquiry |
FLT4-2016MCL | Recombinant Mouse FLT4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1594 | Flt4 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionFLT4 protein is associated with various tumor-related markers such as malignant lymphoma, breast cancer, and lung cancer.
FLT4 protein is a key regulator of lymphedema and plays an important role in lymphangiogenesis and lymphatic drainage.
Yes, mutations in the FLT4 protein can lead to congenital lymphedema, a condition caused by abnormal lymphatic vessel development.
The protein is considered an important target in anticancer therapy, and inhibition of its activity may reduce tumor angiogenesis and metastasis.
FLT4 protein plays an important role in pulmonary hypertension, and upregulation of its activity may lead to pathological changes such as vascular remodeling and pulmonary artery stenosis.
This is involved in the regulation of angiogenesis and lymphangiogenesis by binding to vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D).
Customer Reviews (3)
Write a reviewThe catalytic activity of FLT4 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and its application potential is great.
We were reassured that the quality of FLT4 was consistent.
Using FLT4 for experiments, I can focus more on experimental design and data analysis without worrying about the reproducibility of experimental results.
Ask a Question for All Flt4 Products
Required fields are marked with *
My Review for All Flt4 Products
Required fields are marked with *
Inquiry Basket