Recombinant Rat Intercellular Adhesion Molecule 1

• Cat.No.: Icam1-1793R

Specification

• Cat. No.: Icam1-1793R
• Description: Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies.
• Molecular Weight: The predicted molecular weight of Recombinant Rat ICAM-1 is Mr 78 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110-125 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Icam1 intercellular adhesion molecule 1 [ Rattus norvegicus ]
• Synonyms: Icam1; intercellular adhesion molecule 1; CD54; ICAM; cell adhesion molecule; ligand for leukocyte adhesion molecule LFA-1
• Gene ID: 25464
• mRNA Refseq: NM_012967
• Protein Refseq: NP_037099
• UniProt ID: Q00238
• Chromosome Location: 8q13
• Pathway: Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity
• Function: integrin binding; protein binding