Recombinant Human RIPK2

• Cat.No.: RIPK2-29983TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-299 of Human RIP2, was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 59 kDa.

Specification

• Description: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
• Tissue specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 1 CARD domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
• Official Symbol: RIPK2
• Synonyms: RIPK2; receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2
• Gene ID: 8767
• mRNA Refseq: NM_003821
• Protein Refseq: NP_003812
• MIM: 603455
• Uniprot ID: O43353
• Chromosome Location: 8q21
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem
• Function: ATP binding; CARD domain binding; CARD domain binding; LIM domain binding; non-membrane spanning protein tyrosine kinase activity