Recombinant Human RRM1
Cat.No. : | RRM1-29473TH |
Product Overview : | Recombinant fragment of Human RRM1 (amino acids 644-753) with N terminal proprietary tag; Predicted MWt 37.73 kDa including the tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. |
Protein length : | 110 amino acids |
Molecular Weight : | 37.730kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | DLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSM HFYGWKQGLKTGMYYLRTRPAANPIQFTLN |
Sequence Similarities : | Belongs to the ribonucleoside diphosphate reductase large chain family.Contains 1 ATP-cone domain. |
Gene Name : | RRM1 ribonucleotide reductase M1 [ Homo sapiens ] |
Official Symbol : | RRM1 |
Synonyms : | RRM1; ribonucleotide reductase M1; ribonucleotide reductase M1 polypeptide; ribonucleoside-diphosphate reductase large subunit; |
Gene ID : | 6240 |
mRNA Refseq : | NM_001033 |
Protein Refseq : | NP_001024 |
MIM : | 180410 |
Uniprot ID : | P23921 |
Chromosome Location : | 11p15.5 |
Pathway : | E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; |
Function : | ATP binding; oxidoreductase activity; purine nucleotide binding; ribonucleoside-diphosphate reductase activity; ribonucleoside-diphosphate reductase activity; |
Products Types
◆ Recombinant Protein | ||
Rrm1-5626M | Recombinant Mouse Rrm1 Protein, Myc/DDK-tagged | +Inquiry |
RRM1-7813M | Recombinant Mouse RRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
RRM1-3853R | Recombinant Rhesus Macaque RRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
RRM1-1509H | Recombinant Human RRM1 Protein (1-792 aa), His-tagged | +Inquiry |
RRM1-1318H | Recombinant Human RRM1 protein(Met1-Ser792), His&GST-tagged | +Inquiry |
◆ Lysates | ||
RRM1-001HCL | Recombinant Human RRM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket