Recombinant Mouse Interleukin 3 Receptor, Alpha Chain

• Cat.No.: Il3ra-1755M

Specification

• Cat. No.: Il3ra-1755M
• Description: Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-3 Rα is Mr 61.0 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Il3ra interleukin 3 receptor, alpha chain [ Mus musculus ]
• Synonyms: Il3ra; interleukin 3 receptor, alpha chain; CD123; SUT-1; CDw123; Il-3 alpha subunit; IL-3 receptor alpha chain; IL-3 receptor alpha SP2 isoform
• Gene ID: 16188
• mRNA Refseq: NM_008369
• Protein Refseq: NP_032395
• UniProt ID: P26952
• Chromosome Location: 14 A2; 14 1.5 cM
• Pathway: Apoptosis; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
• Function: cytokine receptor activity; receptor activity