Recombinant Mouse Interleukin 7 Receptor

• Cat.No.: Il7r-1758M

Specification

• Cat. No.: Il7r-1758M
• Description: IL-7 receptor alpha (IL-7Ra), also known as CD127, is expressed on bone marrow lymphoid precursors, pro-B cells, monocytes/macrophages, natural killer (NK) cells, naïve T cells and memory CD4+ and CD8+ T cells. IL-7Ra is also expressed on non-immune somatic cells such as intestinal colorectal and renal carcinoma cell lines and keratinocytes. IL-7Ralpha displays a synergistic decrease in the number of T-cell, NK-cell and multipotent progenitors in the thymus, indicating that these distinct survival pathways converge to promote the development of multipotent lymphoid progenitors.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-7 Rα is Mr 51.6 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55-60 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain..
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Il7r interleukin 7 receptor [ Mus musculus ]
• Synonyms: Il7r; interleukin 7 receptor; CD127; MGC107557; IL-7Ralpha; 15 A1; IL-7 receptor alpha chain; interleukin 7 receptor alpha chain
• Gene ID: 16197
• mRNA Refseq: NM_008372
• Protein Refseq: NP_032398
• UniProt ID: P16872
• Chromosome Location: 15 4.6 cM
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Primary immunodeficiency
• Function: cytokine receptor activity; receptor activity