Recombinant Human SELL, Fc-tagged

• Cat.No.: SELL-27885TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-343 of Human CD62L fused to the Fc region of human IgG1 , expressed in modified human 293 cells.

Specification

• Description: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
• Conjugation: Fc
• Tissue specificity: Expressed in B cell lines and T lymphocytes.
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical Sequence:WTYHYSEKPMNWQRARRFCRDNYTDLVAI QNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNK SLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDD ACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCD VGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSS QCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEP LSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKK KTICESSGIWSNPSPICQKLDKSFSMIKEGDWIPKVDK KVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMI SRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLNGKEYKCRVSNKALP APIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK
• Sequence Similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 2 Sushi (CCP/SCR) domains.

Gene Information

• Gene Name: SELL selectin L [ Homo sapiens ]
• Official Symbol: SELL
• Synonyms: SELL; selectin L; LNHR, LYAM1, lymphocyte adhesion molecule 1; L-selectin; CD62L; hLHRc; LAM 1; LAM1; Leu 8; LSEL; Lyam 1; PLNHR
• Gene ID: 6402
• mRNA Refseq: NM_000655
• Protein Refseq: NP_000646
• MIM: 153240
• Uniprot ID: P14151
• Chromosome Location: 1q23-q25
• Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem
• Function: carbohydrate binding; cell adhesion molecule binding; glycosphingolipid binding; heparin binding; protease binding