Recombinant Human SELP

• Cat.No.: SELP-27886TH
• Product Overview: Recombinant fragment, corresponding to the signal peptide and the extracellular amino acids 1-771 of Human CD62P, expressed in modified human 293 cells, 85kDa.

Specification

• Description: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
• Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS
• Storage: Shipped at 4°C. After reconstitution store at -20oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: Theoretical sequence:MANCQIAILYQRFQRVVFGISQLLC FSAL ISELTNQKEVAAWTYHYSTKAYSWN ISRKYCQNRYTDL VAIQNKNEIDYLNKVLPYYSSYYWI GIRKNNKTWTWVGTK KALTNEAENWADNEPNNKRNNEDCV EIYIKSPSAPGKW NDEHCLKKKHALCYTASCQDMSCSK QGECLETIGNYTCSC YPGFYGPECEYVRECGELELPQHVL MNCSHPLGNFSFN SQCSFHCTDGYQVNGPSKLECLASG IWTNKPPQCLAAQ CPPLKIPERGNMTCLHSAKAFQHQS SCSFSCEEGFALVGP EVVQCTASGVWTAPAPVCKAVQCQH LEAPNEGTMDCVH PLTAFAYGSSCKFECQPGYRVRGLD MLRCIDSGHWSAP LPTCEAISCEPLESPVHGSMDCSPS LRAFQYDTNCSFRCA EGFMLRGADIVRCDNLGQWTAPAPV CQALQCQDLPVPN EARVNCSHPFGAFRYQSVCSFTCNE GLLLVGASVLQCLATGNWNSVPPEC QAIPCTPLLSPQNGTMTCVQPLGSS SYK STCQFICDEGYSLSGPERLDCTRSG RWTDSPPMCEAIK CPELFAPEQGSLDCSDTRGEFNVGS TCHFSCNNGFKLEGP NNVECTTSGRWSATPPTCKGIASLP TPGVQCPALTTPG QGTMYCRHHPGTFGFNTTCYFGCNA GFTLIGDSTLSCR PSGQWTAVTPACRAVKCSELHVNKP IAMNCSNLWGNFSYG SICSFHCLEGQLLNGSAQTACQENG HWSTTVPTCQAGP LTIQEA
• Sequence Similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 9 Sushi (CCP/SCR) domains.

Gene Information

• Gene Name: SELP selectin P (granule membrane protein 140kDa, antigen CD62) [ Homo sapiens ]
• Official Symbol: SELP
• Synonyms: SELP; selectin P (granule membrane protein 140kDa, antigen CD62); GRMP, selectin P (granule membrane protein 140kD, antigen CD62); P-selectin; CD62; CD62P; GMP140; PADGEM; PSEL
• Gene ID: 6403
• mRNA Refseq: NM_003005
• Protein Refseq: NP_002996
• Uniprot ID: P16109
• Chromosome Location: 1q22-q25
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem
• Function: calcium-dependent protein binding; eukaryotic cell surface binding; fucose binding; glycoprotein binding; glycosphingolipid binding