Recombinant Mouse Left Right Determination Factor 1
Cat.No. : | Lefty1-1765M |
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- Gene Information
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Cat. No. : | Lefty1-1765M |
Description : | Lefty proteins are signaling ligands that act in opposition to the NODAL protein. During vertebrate development they regulate the degree of left-right asymmetry by controlling the spatiotemporal influence of the NODAL protein. The role of Lefty1 is to restrict the expression of Lefty2 and Nodal to the left side, and that Lefty2 or Nodal encode a signal for "leftness." Lefty2 serves as a feedback inhibitor to restrict the range of nodal signaling during establishment of the left-right axis. |
Molecular Weight : | By N-terminal sequencing, two peptides corresponding to mouse Lefty-1 propeptide (with Leu 22 at the amino-terminus) and mature Lefty-1 (with a histidine residue at the amino-terminus) are present in the recombinant preparation. In SDS-PAGE under reducing conditions, the propeptide and mature Lefty-1 have apparent molecular masses of 12 kDa and 36 kDa, respectively. The two peptides apparently remained associated after processing and during protein purification. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Lefty1 left right determination factor 1 [ Mus musculus ] |
Synonyms : | Lefty1; left right determination factor 1; Ebaf; Leftb; Stra3; Tgfb4; lefty; lefty-1; AI450052; OTTMUSP00000023876; left-right determination, factor B |
Gene ID : | 13590 |
mRNA Refseq : | NM_010094 |
Protein Refseq : | NP_034224 |
UniProt ID : | Q64280 |
Chromosome Location : | 1F |
Pathway : | TGF-beta signaling pathway |
Function : | cytokine activity; growth factor activity; transforming growth factor beta receptor binding |
Products Types
◆ Recombinant Protein | ||
Lefty1-371R | Recombinant Rat Lefty1 Protein, His/GST-tagged | +Inquiry |
LEFTY1-367H | Recombinant Human LEFTY1 Protein, His-tagged | +Inquiry |
Lefty1-10587M | Recombinant Mouse Lefty1 Protein, His (Fc)-Avi-tagged | +Inquiry |
LEFTY1-5033M | Recombinant Mouse LEFTY1 Protein, His (Fc)-Avi-tagged | +Inquiry |
LEFTY1-003H | Recombinant Human LEFTY1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
LEFTY1-980HCL | Recombinant Human LEFTY1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCombination therapies involving LEFTY1 are being investigated to enhance treatment efficacy and reduce the risk of resistance development.
Some clinical trials are exploring the therapeutic potential of LEFTY1, particularly in cancer treatment and tissue regeneration.
LEFTY1 interacts with various signaling pathways, influencing cellular processes involved in development, immune response, and disease progression.
LEFTY1 has shown potential clinical applications in various fields, including cancer research and regenerative medicine.
LEFTY1 has demonstrated the ability to influence stem cell differentiation and tissue repair, making it a potential candidate for regenerative medicine.
Customer Reviews (3)
Write a reviewThe knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.
Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.
Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.
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