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Recombinant Mouse Left Right Determination Factor 1

Cat.No. : Lefty1-1765M
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  • Gene Information
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Cat. No. : Lefty1-1765M
Description : Lefty proteins are signaling ligands that act in opposition to the NODAL protein. During vertebrate development they regulate the degree of left-right asymmetry by controlling the spatiotemporal influence of the NODAL protein. The role of Lefty1 is to restrict the expression of Lefty2 and Nodal to the left side, and that Lefty2 or Nodal encode a signal for "leftness." Lefty2 serves as a feedback inhibitor to restrict the range of nodal signaling during establishment of the left-right axis.
Molecular Weight : By N-terminal sequencing, two peptides corresponding to mouse Lefty-1 propeptide (with Leu 22 at the amino-terminus) and mature Lefty-1 (with a histidine residue at the amino-terminus) are present in the recombinant preparation. In SDS-PAGE under reducing conditions, the propeptide and mature Lefty-1 have apparent molecular masses of 12 kDa and 36 kDa, respectively. The two peptides apparently remained associated after processing and during protein purification.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Lefty1 left right determination factor 1 [ Mus musculus ]
Synonyms : Lefty1; left right determination factor 1; Ebaf; Leftb; Stra3; Tgfb4; lefty; lefty-1; AI450052; OTTMUSP00000023876; left-right determination, factor B
Gene ID : 13590
mRNA Refseq : NM_010094
Protein Refseq : NP_034224
UniProt ID : Q64280
Chromosome Location : 1F
Pathway : TGF-beta signaling pathway
Function : cytokine activity; growth factor activity; transforming growth factor beta receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can LEFTY1 be used in combination with other treatments? 03/28/2022

Combination therapies involving LEFTY1 are being investigated to enhance treatment efficacy and reduce the risk of resistance development.

Are there any ongoing clinical trials involving LEFTY1? 09/11/2018

Some clinical trials are exploring the therapeutic potential of LEFTY1, particularly in cancer treatment and tissue regeneration.

How does LEFTY1 interact with other signaling pathways in the body? 05/16/2018

LEFTY1 interacts with various signaling pathways, influencing cellular processes involved in development, immune response, and disease progression.

How is LEFTY1 protein associated with clinical applications? 12/22/2017

LEFTY1 has shown potential clinical applications in various fields, including cancer research and regenerative medicine.

How does LEFTY1 contribute to tissue regeneration? 06/27/2017

LEFTY1 has demonstrated the ability to influence stem cell differentiation and tissue repair, making it a potential candidate for regenerative medicine.

Customer Reviews (3)

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Reviews
02/12/2021

    The knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.

    08/22/2018

      Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.

      10/02/2016

        Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.

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