Native Human SERPINE1
Cat.No. : | SERPINE1-29522TH |
Product Overview : | Full length Human PAI1. Molecular weigth 43 kDa; |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Tissue specificity : | Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.1M Sodium chloride, 0.05M Sodium phosphate, 1mM EDTA, pH 6.6 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the serpin family. |
Gene Name : | SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [ Homo sapiens ] |
Official Symbol : | SERPINE1 |
Synonyms : | SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI1, PLANH1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inh |
Gene ID : | 5054 |
mRNA Refseq : | NM_000602 |
Protein Refseq : | NP_000593 |
MIM : | 173360 |
Uniprot ID : | P05121 |
Chromosome Location : | 7q21.3-q22 |
Pathway : | Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; |
Function : | peptidase inhibitor activity; protease binding; protein binding; contributes_to receptor binding; serine-type endopeptidase inhibitor activity; |
Products Types
◆ Native Protein | ||
SERPINE1-5514R | Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 | +Inquiry |
◆ Lysates | ||
SERPINE1-001RCL | Recombinant Rat SERPINE1 cell lysate | +Inquiry |
SERPINE1-2383HCL | Recombinant Human SERPINE1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0782 | SERPINE1 (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.
Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.
SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.
The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.
In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.
In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.
Customer Reviews (3)
Write a reviewIt has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
When used for experiments, the experimental conditions and results are highly repeatable.
SERPINE1 has good solubility and is easy to operate and purify.
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