Recombinant Human SIRT2
Cat.No. : | SIRT2-30564TH |
Product Overview : | Full-length recombinant Human SIRT2 with an N-terminal tag. MWt 64kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. |
Protein length : | 389 amino acids |
Molecular Weight : | 64.000kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulatio |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain. |
Gene Name : | SIRT2 sirtuin 2 [ Homo sapiens ] |
Official Symbol : | SIRT2 |
Synonyms : | SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2; |
Gene ID : | 22933 |
mRNA Refseq : | NM_001193286 |
Protein Refseq : | NP_001180215 |
MIM : | 604480 |
Uniprot ID : | Q8IXJ6 |
Chromosome Location : | 19q13 |
Pathway : | Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem; |
Function : | NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; |
Products Types
◆ Recombinant Protein | ||
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SIRT2-31405TH | Active Recombinant Human SIRT2 Protein (50-356), C-6xHis tagged | +Inquiry |
SIRT2-107H | Recombinant Human SIRT2 Protein, His-tagged | +Inquiry |
SIRT2-5067R | Recombinant Rat SIRT2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SIRT2-23H | Recombinant Human SIRT2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
SIRT2-1834HCL | Recombinant Human SIRT2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1083 | SIRT2 Inhibitor Screening Assay Kit (Fluorometric) | +Inquiry |
Kit-2026 | SIRT2 Direct Fluorescent Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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