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Recombinant Human SIRT2, His-tagged

Cat.No. : SIRT2-30567TH
Product Overview : Recombinant fragment, corresponding to amino acids 50-356 of Human SIRT2, with C-terminal His tag, 35.5 kDa.
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Description : This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Conjugation : HIS
Source : E. coli
Tissue specificity : Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulatio
Biological activity : Specific Activity: 1.4 U/μg. One U =1 pmol/min.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.
Gene Name : SIRT2 sirtuin 2 [ Homo sapiens ]
Official Symbol : SIRT2
Synonyms : SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2;
Gene ID : 22933
mRNA Refseq : NM_001193286
Protein Refseq : NP_001180215
MIM : 604480
Uniprot ID : Q8IXJ6
Chromosome Location : 19q13
Pathway : Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem;
Function : NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does SIRT2 participate in the regulation of cellular stress responses? 02/09/2022

SIRT2 is involved in stress response pathways, deacetylating and modulating the activity of stress-responsive proteins, contributing to cellular adaptation to various stress conditions.

How does SIRT2 contribute to the regulation of cellular metabolism? 07/15/2021

SIRT2 influences cellular metabolism by deacetylating enzymes involved in glycolysis, fatty acid metabolism, and mitochondrial function, impacting overall energy homeostasis.

Explain the molecular mechanisms underlying SIRT2-mediated deacetylation of target proteins. 11/30/2020

SIRT2 uses NAD+ as a cofactor to remove acetyl groups from lysine residues, a process that links cellular metabolic state to protein acetylation and deacetylation.

Discuss the role of SIRT2 in the regulation of cell cycle progression. 08/19/2019

SIRT2 influences cell cycle progression by deacetylating key regulators, such as cyclin-dependent kinases (CDKs) and checkpoint proteins, impacting cell cycle checkpoints and progression.

Discuss the role of SIRT2 in neurodegenerative diseases and its potential as a therapeutic target. 01/04/2018

SIRT2 has been implicated in neurodegenerative diseases, and modulating its activity is explored as a potential therapeutic strategy for conditions such as Parkinson's disease.

Customer Reviews (3)

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Reviews
04/15/2021

    Efficient and knowledgeable customer service—made our purchase straightforward.

    11/02/2020

      This recombined protein is our go-to for dependable and accurate results.

      08/30/2018

        Punctual delivery is crucial, and this product arrived right on time.

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