Active Recombinant Human SIRT2 Protein (50-356), C-6xHis tagged

• Cat.No.: SIRT2-31405TH
• Product Overview: Recombinant Human SIRT2 Protein (50-356) with C-6xHis tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
• Source: E. coli
• Species: Human
• Tag: C-6×His
• Form: Aqueous buffer solution
• Bio-activity: ≥1.0 pmol/min/μg.
• Molecular Mass: 36 kDa
• Protein Length: 50-356
• Purity: ≥90%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Usage: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage.
• Storage: At least 6 months at -80 centigrade.
• Storage Buffer: 40 mM Tris, pH 8.0, 110 mM NaCl, 2.1 mM KCl, and 20% glycerol.
• Shipping: At -80 centigrade.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: SIRT2 sirtuin 2 [ Homo sapiens (human) ]
• Official Symbol: SIRT2
• Synonyms: SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; regulatory protein SIR2 homolog 2; silent information regulator 2; sir2-related protein type 2; sirtuin type 2; EC 2.3.1.286
• Gene ID: 22933
• mRNA Refseq: NM_012237
• Protein Refseq: NP_036369
• MIM: 604480
• UniProt ID: Q8IXJ6