Recombinant Human Methylthioadenosine Phosphorylase, GST-tagged

• Cat.No.: MTAP-422H

Specification

• Cat. No.: MTAP-422H
• ProductOverview: Recombinant human MTAP (amino acids 2-end), with Nterminal GST tag, MW=57 kDa, expressed in an E. coli expression system.
• Description: S-methyl-5''-thioadenosine phosphorylase is an enzyme that in humans is encoded by the MTAP gene. This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
• Source: E. coli.
• Purity: >80%.
• FormulatedIn: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 10% glycerol, and 3 mM DTT.
• Stability: >6 months at -80°C

Gene Information

• Gene Name: MTAP methylthioadenosine phosphorylase [ Homo sapiens ]
• Synonyms: MTAP; methylthioadenosine phosphorylase; MSAP; c86fus; S-methyl-5''-thioadenosine phosphorylase; EC 2.4.2.28; 5''-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; OTTHUMP00000021152; MeSAdo phosphorylase
• Gene ID: 4507
• mRNA Refseq: NM_002451
• Protein Refseq: NP_002442
• MIM: 156540
• UniProt ID: Q13126
• Chromosome Location: 9p21
• Pathway: Cysteine and methionine metabolism; Metabolic pathways
• Function: S-methyl-5-thioadenosine phosphorylase activity; phosphorylase activity