Recombinant Human SMAD3
Cat.No. : | SMAD3-31191TH |
Product Overview : | Recombinant full length human SMAD3with an N-terminal enzyme tag. M.Wt ~77 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. |
Source : | E. coli |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM PMSF, 0.25mM DTT, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the dwarfin/SMAD family.Contains 1 MH1 (MAD homology 1) domain.Contains 1 MH2 (MAD homology 2) domain. |
Gene Name : | SMAD3 SMAD family member 3 [ Homo sapiens ] |
Official Symbol : | SMAD3 |
Synonyms : | SMAD3; SMAD family member 3; MAD, mothers against decapentaplegic homolog 3 (Drosophila) , MADH3, SMAD, mothers against DPP homolog 3 (Drosophila); mothers against decapentaplegic homolog 3; HsT17436; JV15 2; |
Gene ID : | 4088 |
mRNA Refseq : | NM_001145102 |
Protein Refseq : | NP_001138574 |
MIM : | 603109 |
Uniprot ID : | P84022 |
Chromosome Location : | 15q21-q22 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adipogenesis, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; |
Function : | R-SMAD binding; RNA polymerase II activating transcription factor binding; beta-catenin binding; chromatin DNA binding; co-SMAD binding; |
Products Types
◆ Recombinant Protein | ||
Smad3-5951M | Recombinant Mouse Smad3 Protein, Myc/DDK-tagged | +Inquiry |
SMAD3-1918H | Recombinant Human SMAD3 Protein, MYC/DDK-tagged | +Inquiry |
Smad3-305M | Recombinant Mouse Smad3 Protein, His-tagged | +Inquiry |
SMAD3-304H | Recombinant Human SMAD3 Protein, His-tagged | +Inquiry |
SMAD3-2041H | Recombinant Human SMAD3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SMAD3-001MCL | Recombinant Mouse SMAD3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe expression level of SMAD3 protein can be detected by immunohistochemistry, western blotting, real-time PCR and other techniques. At the same time, the activity of SMAD3 protein can be assessed by detecting the phosphorylation level and the amount of SMAD3 protein within the nucleus.
interaction between SMAD3 protein and other proteins is regulated by a variety of factors, including phosphorylation, methylation, acetylation and other modifications, and interactions with other proteins. These factors can affect the interaction between SMAD3 protein and other proteins, and then affect the regulation process of TGF-β signal transduction pathway.
In the TGF-β signaling pathway, SMAD3 protein is activated by TGF-β to form complexes with other SMAD proteins, and then enters the nucleus to regulate the expression of specific genes, thereby affecting the growth, differentiation, apoptosis and immune response of cells.
expression level of SMAD3 protein is regulated by a variety of factors, including gene transcription, translation, modification, and degradation. These factors can affect the expression level of SMAD3 protein, which in turn affects the growth, differentiation and apoptosis of cells.
The main function of SMAD3 protein is to transmit signals in the TGF-β signal transduction pathway and regulate cell growth, differentiation, apoptosis and immune response.
SMAD3 protein is a protein that plays a key role in intracellular signal transduction and belongs to the SMAD family. It is an effector molecule in the transforming growth factor-β (TGF-β) signaling pathway.
Customer Reviews (3)
Write a reviewHigh expression level, good stability, suitable for high precision experiments.
Compared with other brands I have used, this brand is more stable and reliable.
Strong antibacterial activity, not easy to be contaminated.
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